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Shift Work And Breast Cancer. A 2007 World Health Organization review concluded mainly from animal evidence that shift work involving circadian disruption is probably carcinogenic to humans. In most studies an excess risk of breast cancer was found mainly among women who had worked night shifts for many years or at a high frequency or. Risk was also not associated with frequency duration or cumulative amount of night-shift work. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link.
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Interestingly after we had completed our literature search 2009 a new epidemiological study on night-shift work and the risk of breast cancer was published by Chinese researchers in April 2010. She noted that the International Agency for Research on Cancer currently classifies night shift work as probably carcinogenic and the agency is in the process of reviewing the literature on the subject. Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleepwake cycles. We calculated incremental risk ratios RR per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose-response meta-analysis. The pooled relative risk RR and 95 confidence intervals CIs of breast cancer for short-term night-shift workers 10 years was 113 95 CI 103-124 p 0008 I 2 713 and for long-term night-shift workers 10 years was 108 95 CI 099-117 p 009 I 2 422 with moderate to substantial statistical heterogeneity observed in both analyses. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link.
There were no indications of effect modification.
The International Agency for Research on Cancer IARC has classified shift work as a possible human carcinogen. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link. The ruling comes a year after the the International Association for Research on Cancer weighed the evidence around shift-work and somewhat surprisingly concluded that there was probably a link to breast cancer. Shift work and breast cancer she said. Risk was also not associated with frequency duration or cumulative amount of night-shift work. In this prospective population-based cohort study night-shift workwhich was reconstructed both with a job-exposure matrix and through interviews of.
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We calculated incremental risk ratios RR per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose-response meta-analysis. Night shift work elevated the risk of breast cancer in a doseresponse way which was consistent with previous studies. For every 5 years of night shift work the risk of breast cancer in women increased by 33 OR 1033. 1 It is intriguing that the progression of breast prostate and colorectal cancer are each influenced by sex hormones. Shift Work and Breast Cancer The rates of shift work outside of daylight hours have increased in recent years and nighttime shift work is now considered a potential carcinogenic occupational exposure.
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It has been proposed that night shift work could increase breast cancer incidence. Research on circadian disruption and cancer was stimulated by the 2007 evaluation by the International Agency for Research on Cancer of light at night and circadian rhythm disruption as probably carcinogenic to humans1 Circadian rhythm disruption ultimately affects a large part of the population in modern societies and not only those in shift work. In 2007 the International Agency for Research on Cancer IARC classified shift work that involves circadian disruption as probably carcinogenic to humans based on limited evidence from eight epidemiologic studies on breast cancer in addition to sufficient evidence from animal experiments. We searched multiple databases for studies comparing women in shift work to those with no-shift work reporting incidence of breast cancer. If the link is confirmed night shift work could become a significant public health concern.
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Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleepwake cycles. For every 5 years of night shift work the risk of breast cancer in women increased by 33 OR 1033. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link. Based on the hypothesis that longer duration of night shift work may be associated with a higher incidence of breast cancer we also categorized workers by duration of night shift work. In most studies an excess risk of breast cancer was found mainly among women who had worked night shifts for many years or at a high frequency or.
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An estimated 15 to 20 percent of the working population in industrialized countries are employed in some type of permanent night and. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link. One of the first studies confirming the hypothesis that shift work might increase the risk of breast cancer was a casecontrol study conducted in Denmark which found that the relative risk of breast cancer in shift workers was 15 and in shift workers of over 6 years it was 17 demonstrating the direct relationship between shift work and an increased risk of breast. A 2007 World Health Organization review concluded mainly from animal evidence that shift work involving circadian disruption is probably carcinogenic to humans. A substantial proportion of women in the general population are exposed to night shift.
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This systematic review and meta-analysis therefore aimed to update the current evidence regarding the relationship between night-shift work duration and breast cancer risk. Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleepwake cycles. The results of systematic on this topic is contradictory. Moreover studies among nurses and other night shift workers showed increased risk of breast cancer that was unexplained by reproductive history lifestyle factors body mass index or socioeconomic status. There is an emerging body of evidence that shift work and night work in particular is linked with the development of breast cancer but further work to confirm this causal link is still being.
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The majority of the epidemiological studies performed to date have focused on the association between shift work and breast cancer risk few studies have reported an increased risk of other cancers including colorectal cancer endometrial cancer. Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleep-wake c. The International Agency for Research on Cancer IARC has classified shift work as a possible human carcinogen. The results of systematic on this topic is contradictory. It may be premature to consider shift work a cause of cancer.
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For every 5 years of night shift work the risk of breast cancer in women increased by 33 OR 1033. The lack of an association between night-shift work and breast cancer adds to the inconsistent epidemiologic evidence. Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleep-wake c. Specifically the IARC Working Group concluded that there was limited evidence in humans that night shift work causes breast prostate and colorectal cancer in this latest evaluation. Night shift work elevated the risk of breast cancer in a doseresponse way which was consistent with previous studies.
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This systematic review and meta-analysis therefore aimed to update the current evidence regarding the relationship between night-shift work duration and breast cancer risk. A 2007 World Health Organization review concluded mainly from animal evidence that shift work involving circadian disruption is probably carcinogenic to humans. Shift work and breast cancer she said. The International Agency for Research on Cancer IARC has classified shift work as a possible human carcinogen. Fewer than 10 10 to 19 and 20 or more years in the Million Women Study and EPIC-Oxford duration was not available for UK Biobank.
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This systematic review and meta-analysis therefore aimed to update the current evidence regarding the relationship between night-shift work duration and breast cancer risk. The majority of the epidemiological studies performed to date have focused on the association between shift work and breast cancer risk few studies have reported an increased risk of other cancers including colorectal cancer endometrial cancer. Specifically the IARC Working Group concluded that there was limited evidence in humans that night shift work causes breast prostate and colorectal cancer in this latest evaluation. The aim of this review is a critical update of the IARC evaluation including. Interestingly after we had completed our literature search 2009 a new epidemiological study on night-shift work and the risk of breast cancer was published by Chinese researchers in April 2010.
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In most studies an excess risk of breast cancer was found mainly among women who had worked night shifts for many years or at a high frequency or. The International Agency for Research on Cancer IARC has classified shift work as a possible human carcinogen. There were no indications of effect modification. The results of systematic on this topic is contradictory. Risk was also not associated with frequency duration or cumulative amount of night-shift work.
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Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleepwake cycles. The International Agency for Research on Cancer IARC has classified shift work as a possible human carcinogen. She noted that the International Agency for Research on Cancer currently classifies night shift work as probably carcinogenic and the agency is in the process of reviewing the literature on the subject. The results of systematic on this topic is contradictory. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link.
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The pooled relative risk RR and 95 confidence intervals CIs of breast cancer for short-term night-shift workers 10 years was 113 95 CI 103-124 p 0008 I 2 713 and for long-term night-shift workers 10 years was 108 95 CI 099-117 p 009 I 2 422 with moderate to substantial statistical heterogeneity observed in both analyses. This systematic review and meta-analysis therefore aimed to update the current evidence regarding the relationship between night-shift work duration and breast cancer risk. A 2007 World Health Organization review concluded mainly from animal evidence that shift work involving circadian disruption is probably carcinogenic to humans. If the link is confirmed night shift work could become a significant public health concern. Interestingly after we had completed our literature search 2009 a new epidemiological study on night-shift work and the risk of breast cancer was published by Chinese researchers in April 2010.
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Light at night exposure lower melatonin production and the production of stress-related mediators disrupt normal sleepwake cycles. There were no indications of effect modification. Ed posted a while ago about the strength of this evidence and to summarise there does appear to be a statistical link. We calculated incremental risk ratios RR per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose-response meta-analysis. The results of systematic on this topic is contradictory.
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The aim of this review is a critical update of the IARC evaluation including. It will be interesting to see whether they will downgrade night shift work as a risk factor for breast cancer said Hill. We calculated incremental risk ratios RR per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose-response meta-analysis. Night shift work elevated the risk of breast cancer in a doseresponse way which was consistent with previous studies. An estimated 15 to 20 percent of the working population in industrialized countries are employed in some type of permanent night and.
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Moreover studies among nurses and other night shift workers showed increased risk of breast cancer that was unexplained by reproductive history lifestyle factors body mass index or socioeconomic status. A number of studies also suggest long-term shift work is associated with a higher risk of certain types of cancer especially breast cancer. She noted that the International Agency for Research on Cancer currently classifies night shift work as probably carcinogenic and the agency is in the process of reviewing the literature on the subject. Ad Trusted US Based Supplier of Research Biologicals Including Human Cancer Serum. Fewer than 10 10 to 19 and 20 or more years in the Million Women Study and EPIC-Oxford duration was not available for UK Biobank.
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An estimated 15 to 20 percent of the working population in industrialized countries are employed in some type of permanent night and. It will be interesting to see whether they will downgrade night shift work as a risk factor for breast cancer said Hill. The lack of an association between night-shift work and breast cancer adds to the inconsistent epidemiologic evidence. One of the first studies confirming the hypothesis that shift work might increase the risk of breast cancer was a casecontrol study conducted in Denmark which found that the relative risk of breast cancer in shift workers was 15 and in shift workers of over 6 years it was 17 demonstrating the direct relationship between shift work and an increased risk of breast. If the link is confirmed night shift work could become a significant public health concern.
Source: pinterest.com
The pooled relative risk RR and 95 confidence intervals CIs of breast cancer for short-term night-shift workers 10 years was 113 95 CI 103-124 p 0008 I 2 713 and for long-term night-shift workers 10 years was 108 95 CI 099-117 p 009 I 2 422 with moderate to substantial statistical heterogeneity observed in both analyses. A number of studies also suggest long-term shift work is associated with a higher risk of certain types of cancer especially breast cancer. A substantial proportion of women in the general population are exposed to night shift. Risk was also not associated with frequency duration or cumulative amount of night-shift work. Interestingly after we had completed our literature search 2009 a new epidemiological study on night-shift work and the risk of breast cancer was published by Chinese researchers in April 2010.
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There were no indications of effect modification. Risk was also not associated with frequency duration or cumulative amount of night-shift work. In this prospective population-based cohort study night-shift workwhich was reconstructed both with a job-exposure matrix and through interviews of. Interestingly after we had completed our literature search 2009 a new epidemiological study on night-shift work and the risk of breast cancer was published by Chinese researchers in April 2010. In most studies an excess risk of breast cancer was found mainly among women who had worked night shifts for many years or at a high frequency or.
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